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KMID : 0043320070300050543
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Archives of Pharmacal Research
2007 Volume.30 No. 5 p.543 ~ p.546
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A New Steroidal Saponin, Yuccalan, from the Leaves of Yucca smalliana
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Jin Yu-Lan
Kuk Ju-Hee
Oh Kyung-Taek
Kim Young-Ju
Piao Xiang-Lan
Park Ro-Dong
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Abstract
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An extract of the leaves of Yucca smalliana Fern. (Agavaceae) showed potential antimicrobial activity. Employing a bioassay linked fractionation method, one of the active principles, namely yuccalan, was isolated as a new steroidal saponin. The structure of the new steroidal saponin was elucidated as 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(3β, 5α, 6α, 25S)- spirostan-3,6,27-triol (1) using various spectroscopic techniques, including IR, MS, 1D and 2D 1H-NMR, and 13C-NMR. The purified yuccalan showed antifungal activities against both Rhizoctonia solani and Fusarium oxysporum.
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KEYWORD
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Antimicrobial activity, Yucca smalliana, 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(3β, 5α, 6α, 25S)-spirostan-3, 6, 27-triol, Yuccalan
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